Maternal Thyroid Hormone Imbalance and Risk of Autism Spectrum Disorder - Takeaways - MDSpire

Maternal Thyroid Hormone Imbalance and Risk of Autism Spectrum Disorder

  • By

  • Leena Elbedour

  • May Weinberg

  • Gal Meiri

  • Analya Michaelovski

  • Idan Menashe

  • November 25, 2025

  • 0 min

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  • 1

    Maternal thyroid hormones are crucial for fetal neurodevelopment, and dysregulation during pregnancy may increase autism spectrum disorder (ASD) risk.

  • 2

    A study of 51,296 singleton births found that combined chronic and gestational hypothyroidism significantly raised ASD risk in offspring.

  • 3

    Adequately treated chronic hypothyroidism was not associated with ASD, indicating that persistent hormonal imbalance poses a greater risk.

  • 4

    Trimester-specific analysis revealed a dose-response effect, with longer exposure to hypothyroidism correlating with higher ASD risk.

  • 5

    The findings highlight the need for routine thyroid function screening and timely treatment during pregnancy to mitigate ASD risk.

Original Source(s)

Maternal Thyroid Hormone Imbalance and Risk of Autism Spectrum Disorder

  • by Leena Elbedour, May Weinberg, Gal Meiri, Analya Michaelovski, Idan Menashe

  • November 25, 2025

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