Midlife Vitamin D Linked to Lower Tau

Higher vitamin D levels in early midlife were tied to lower tau burden on later brain imaging, while no association was seen with amyloid.

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Higher circulating vitamin D levels in early midlife are linked to lower tau deposition on brain imaging 16 years later in dementia-free adults.
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The study involved 435 participants from the Framingham Heart Study, with serum vitamin D measured between 2002 and 2005.
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No association was found between vitamin D levels and amyloid burden in any analyzed model.
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Findings suggest vitamin D may be a modifiable factor related to preclinical tau burden, but causation is not established.
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Limitations include a predominantly White cohort and a long interval between blood sampling and brain imaging.

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