Editorial: Exploring unconventional T cells and CAR-T-cells in cancer immunotherapy

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Unconventional T cells (UCTs) like γδ T cells and MAIT cells are crucial for advancing cancer immunotherapy beyond conventional T cell approaches.
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UCTs exhibit functional plasticity, adapting their roles in response to the tumor microenvironment, which influences cancer progression and patient outcomes.
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iNKT cells show potential as allogeneic CAR-T cell therapy candidates due to their anti-tumor activity and low risk of graft-versus-host disease.
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Metabolic engineering strategies are being developed to enhance CAR-T cell fitness, addressing challenges posed by the hostile tumor microenvironment.
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Innovative CAR-T cell designs, such as dual-target and matrix-remodeling strategies, aim to improve therapeutic efficacy in solid tumors.

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