The role of protein lactylation in skin diseases: from molecular mechanisms to potential therapeutics - Takeaways - MDSpire

The role of protein lactylation in skin diseases: from molecular mechanisms to potential therapeutics

  • By

  • Yue Zhang

  • Zhinan Shi

  • Xiaohui Mo

  • Qiang Ju

  • Zhanyan Pan

  • July 1, 2026

  • 0 min

Share

  • 1

    Lactylation is a post-translational modification linking cellular metabolism to epigenetic regulation via lactate.

  • 2

    This modification influences gene transcription and protein function, impacting metabolic reprogramming and immune responses.

  • 3

    Lactylation plays a significant role in various skin diseases, including psoriasis, atopic dermatitis, and melanoma.

  • 4

    Lactate-mediated lactylation may serve as a novel therapeutic target for skin disorders, with potential inhibitors showing promise.

  • 5

    Research on lactylation in skin diseases is emerging, highlighting its role in disease progression and therapeutic interventions.

Original Source(s)

The role of protein lactylation in skin diseases: from molecular mechanisms to potential therapeutics

  • by Yue Zhang, Zhinan Shi, Xiaohui Mo, Qiang Ju, Zhanyan Pan

  • July 1, 2026

Related Content

Skin barrier dysfunction and correlation with the onset and progression of psoriasis

Letter to the Editor Regarding “Anchored Matching-Adjusted Indirect Comparison of the Long-Term Maintenance of Efficacy of Tralokinumab and Lebrikizumab in Patients with Moderate-to-Severe Atopic Dermatitis”

Effectiveness, Safety, and Drug Survival of Bimekizumab in Chronic Plaque Psoriasis over 2 Years: Real-World Experience from Northern Italy