Nitidine chloride suppresses polo-like kinase 1 via MYCN-associated transcriptional regulation in colorectal cancer: a multi-omics and spatial transcriptomics study - Takeaways - MDSpire

Nitidine chloride suppresses polo-like kinase 1 via MYCN-associated transcriptional regulation in colorectal cancer: a multi-omics and spatial transcriptomics study

  • By

  • Xiao-Jue Huang

  • Liu-Hui Mo

  • Ke-Jun Wu

  • Rong-Quan He

  • Hui Li

  • Gang Chen

  • Li-Min Liu

  • May 12, 2026

  • 0 min

Share

  • 1

    Nitidine chloride (NC) inhibits Polo-like kinase 1 (PLK1) expression in colorectal cancer (CRC), identified as a significant target through multi-omics analysis.

  • 2

    PLK1 is overexpressed in CRC and is involved in cell cycle-related pathways, contributing to tumor progression and poor prognosis.

  • 3

    NC treatment significantly reduces PLK1 levels at both mRNA and protein levels in CRC cells, indicating its potential therapeutic effects.

  • 4

    MYCN was found to be positively correlated with PLK1 expression in CRC, suggesting a regulatory relationship that may influence NC's anti-cancer effects.

  • 5

    The study utilized advanced techniques, including RNA sequencing and molecular dynamics simulations, to elucidate the mechanisms of NC in CRC.

Original Source(s)

Nitidine chloride suppresses polo-like kinase 1 via MYCN-associated transcriptional regulation in colorectal cancer: a multi-omics and spatial transcriptomics study

  • by Xiao-Jue Huang, Liu-Hui Mo, Ke-Jun Wu, Rong-Quan He, Hui Li, Gang Chen, Li-Min Liu

  • May 12, 2026

Related Content

Retraction: Construction and validation of nomogram model for endoscopic submucosal dissection in patients with early colorectal cancer based on intestinal microflora and clinical pathological parameters

  • May 4, 2026

Cytokine and chemokine networks in colorectal cancer

Clinical characteristics, treatment, and outcomes of Oxaliplatin-induced immune thrombocytopenia