Peripheral artery disease in pseudoxanthoma elasticum: Walking capacity on the 6-minute walking test - Takeaways - MDSpire

Peripheral artery disease in pseudoxanthoma elasticum: Walking capacity on the 6-minute walking test

  • By

  • Melanie Haverkamp

  • Frank LJ Visseren

  • Constantijn EVB Hazenberg

  • Pim A de Jong

  • Wilko Spiering

  • June 11, 2026

  • 0 min

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  • 1

    Pseudoxanthoma elasticum (PXE) is linked to pathogenic variants in the ABCC6 gene, causing ectopic calcifications and severe health issues.

  • 2

    Over 50% of PXE patients experience peripheral artery disease (PAD), which is more prevalent and occurs at younger ages compared to the general population.

  • 3

    The study included 162 PXE patients, revealing that walking distances were significantly lower than healthy reference values, particularly in younger individuals.

  • 4

    Among patients with PXE and PAD, the mean walking distance was 496 ± 109 meters, significantly below reference values, indicating reduced walking capacity.

  • 5

    This study is the first to assess walking capacity in PXE, highlighting the need for further research on the relationship between walking decline and cardiovascular risk.

Original Source(s)

Peripheral artery disease in pseudoxanthoma elasticum: Walking capacity on the 6-minute walking test

  • by Melanie Haverkamp, Frank LJ Visseren, Constantijn EVB Hazenberg, Pim A de Jong, Wilko Spiering

  • June 11, 2026

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