Ferroptosis contributes to quercetin-induced anti-cancer activity through blockade of LGR4/NF-κB/GPX4 axis in oral squamous cell carcinoma - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Ferroptosis Mediates the Anti-Cancer Effects of Quercetin by Inhibiting the LGR4/NF-κB/GPX4 Pathway in Oral Squamous Cell Carcinoma

  • By

  • Xiao-jiao Wang

  • Peng Zhang

  • Yue Gao

  • Yu Shao

  • Ling Chen

  • July 14, 2026

Share

  • 1

    Quercetin reduces the viability of oral squamous cell carcinoma (OSCC) cells in a dose-dependent manner.

  • 2

    Co-treatment with the ferroptosis inhibitor liproxstatin-1 counteracts quercetin-induced cell death in OSCC.

  • 3

    Quercetin decreases GPX4 expression in OSCC cells by suppressing the LGR4/NF-κB signaling pathway.

  • 4

    LGR4 activation leads to NF-κB activation and GPX4 transcription, inhibiting ferroptosis in OSCC cells.

  • 5

    The study suggests that quercetin's anti-OSCC activity may involve blocking the LGR4/NF-κB/GPX4 axis.

Original Source(s)

Ferroptosis contributes to quercetin-induced anti-cancer activity through blockade of LGR4/NF-κB/GPX4 axis in oral squamous cell carcinoma

  • by Xiao-jiao Wang, Peng Zhang, Yue Gao, Yu Shao, Ling Chen

  • July 14, 2026

Related Content

Spatial transcriptomics reveals molecular differences associated with malignant transformation in oral epithelial dysplasia

Anatomical site and histological subtype as determinants of Breslow thickness and high-risk features in surgically managed cutaneous melanoma at Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa

Rethinking smoking assessment in head and neck squamous cell carcinoma: are we missing something?