Ferroptosis contributes to quercetin-induced anti-cancer activity through blockade of LGR4/NF-κB/GPX4 axis in oral squamous cell carcinoma - Takeaways - MDSpire

Ferroptosis contributes to quercetin-induced anti-cancer activity through blockade of LGR4/NF-κB/GPX4 axis in oral squamous cell carcinoma

  • By

  • Xiao-jiao Wang

  • Peng Zhang

  • Yue Gao

  • Yu Shao

  • Ling Chen

  • July 14, 2026

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  • 1

    Quercetin reduces the viability of oral squamous cell carcinoma (OSCC) cells in a dose-dependent manner.

  • 2

    Co-treatment with the ferroptosis inhibitor liproxstatin-1 counteracts quercetin-induced cell death in OSCC.

  • 3

    Quercetin decreases GPX4 expression in OSCC cells by suppressing the LGR4/NF-κB signaling pathway.

  • 4

    LGR4 activation leads to NF-κB activation and GPX4 transcription, inhibiting ferroptosis in OSCC cells.

  • 5

    The study suggests that quercetin's anti-OSCC activity may involve blocking the LGR4/NF-κB/GPX4 axis.

Original Source(s)

Ferroptosis contributes to quercetin-induced anti-cancer activity through blockade of LGR4/NF-κB/GPX4 axis in oral squamous cell carcinoma

  • by Xiao-jiao Wang, Peng Zhang, Yue Gao, Yu Shao, Ling Chen

  • July 14, 2026

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