The association between systemic immune-inflammation index and post-stroke depression: a meta-analysis - Takeaways - MDSpire

The association between systemic immune-inflammation index and post-stroke depression: a meta-analysis

  • By

  • Wendi Zhang

  • Geng Chang

  • Zhen Mu

  • June 5, 2026

  • 0 min

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  • 1

    Post-stroke depression (PSD) affects 20–35% of stroke survivors and is linked to poorer recovery and increased mortality.

  • 2

    The systemic immune-inflammation index (SII) is a biomarker indicating systemic inflammation and is calculated from blood cell counts.

  • 3

    High SII levels at admission are associated with a twofold increased risk of developing PSD in stroke patients.

  • 4

    The meta-analysis included seven studies with 2,780 patients, confirming the stability of the association between SII and PSD.

  • 5

    SII may serve as a simple and accessible biomarker for early identification of patients at higher risk for PSD.

Original Source(s)

The association between systemic immune-inflammation index and post-stroke depression: a meta-analysis

  • by Wendi Zhang, Geng Chang, Zhen Mu

  • June 5, 2026

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