Comprehensive multiple risk factor control in cancer survivors to mitigate heart failure risk: insights from a prospective cohort study

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Cancer survivors have a higher risk of heart failure compared to individuals without cancer, necessitating effective risk factor management.
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Joint control of at least five modifiable risk factors in cancer survivors is associated with a 24% reduction in heart failure risk.
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Each additional controlled risk factor correlates with a 12% decrease in heart failure risk among cancer survivors.
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The study analyzed data from 14,466 cancer survivors and 57,864 matched controls from the UK Biobank over a median follow-up of 12.54 years.
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Key risk factors for heart failure in cancer survivors include cancer type, chemotherapy, physical activity, smoking, and body mass index.

European Journal Of Preventive Cardiology

by Yang-Wei Cai, Jing-Wei Gao, Mao-Xiong Wu, Ze-Gui Huang, Guang-Hong Liao, Chuan-Rui Zeng, Pin-Ming Liu, Yang-Xin Chen, Jing-Feng Wang, Hai-Feng Zhang
November 13, 2025

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