Immunogenetic HLA-DQ and IgG serological profiles in individuals with self-reported wheat/gluten sensitivity: a retrospective real-world evidence study - Takeaways - MDSpire

Immunogenetic HLA-DQ and IgG serological profiles in individuals with self-reported wheat/gluten sensitivity: a retrospective real-world evidence study

  • By

  • Andreina White

  • Julie Verzura

  • Mariana White

  • Carol Rodríguez

  • Mercedes White

  • Milaidi García Bravo

  • May 25, 2026

  • 0 min

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  • 1

    The study analyzed immunogenetic and serological profiles in 100 patients with self-reported wheat/gluten sensitivity from 2019 to 2024.

  • 2

    A 100% cumulative frequency of HLA-DQ susceptibility variants was found, indicating a consistent genetic background among symptomatic individuals.

  • 3

    The most prevalent HLA-DQ variants were DQ1 (56%) and DQ2 (54%), with DQ8 and DQ3 also showing significant associations.

  • 4

    Specific IgG reactivity to wheat/gluten was observed in 68% of cases, demonstrating strong correlation and extraordinary cross-reactivity.

  • 5

    The findings support the need for biomarker-informed nutrition strategies to manage systemic manifestations related to wheat exposure.

Original Source(s)

Immunogenetic HLA-DQ and IgG serological profiles in individuals with self-reported wheat/gluten sensitivity: a retrospective real-world evidence study

  • by Andreina White, Julie Verzura, Mariana White, Carol Rodríguez, Mercedes White, Milaidi García Bravo

  • May 25, 2026

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