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Mass Spec Roundup: Molecular Glues, Microbiomes, and Metabolomes
This week’s stories span metabolic activation of protein degradation, frozen-leaf MSI, PASEF benchmarking, microbiota-driven lipid uptake, and chloroplast-made myoglobin.
A multiplexed mass spectrometry screen identified DCAF11 as a molecular glue requiring glutathionylation for DDX18 degradation.
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The platform immobilizes E3 ligases on beads to enhance the discovery of molecular glues and their interactions with cellular proteins.
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In-source freezing improved IR-MALDESI spatial resolution and suppressed metabolic changes in fresh leaf tissue during mass spectrometry imaging.
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A five-way benchmark identified DIA- and Slice-PASEF as the best performers for gut metaproteomics, enhancing protein detection and functional coverage.
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DIA-based approaches generally recovered more proteins than DDA-PASEF, supporting better taxonomic and functional assignments in metaproteomics.
