RFX5 in cancer: context-dependent molecular functions and emerging translational relevance - Takeaways - MDSpire

RFX5 in cancer: context-dependent molecular functions and emerging translational relevance

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RFX5 is a context-dependent transcriptional integrator with implications for cancer immunotherapy and targeted therapy.
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In hepatocellular carcinoma, RFX5 is amplified, promoting tumor growth through the YWHAQ–PI3K/Akt signaling pathway.
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RFX5 enhances antigen presentation and CD8+ T-cell infiltration in immune-inflamed tumors, correlating with better clinical outcomes.
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Altered RFX5 expression is linked to clinical prognosis and immune checkpoint blockade response in specific tumor types.
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RFX5's predictive value as a biomarker remains unverified beyond established immune biomarkers and requires further investigation.

Frontiers In Immunology

Frontiers In Oncology

Frontiers In Oncology

Frontiers In Oncology

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