Mesenchymal R-spondin 3 promotes an immunogenic tumor microenvironment with adaptive immune resistance in human gastric adenocarcinoma - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

R-spondin 3 from Mesenchymal Cells Enhances Immunogenicity and Adaptive Immune Resistance in Human Gastric Adenocarcinoma

  • By

  • Anne-Sophie Fischer

  • Alexander Arnold

  • Hilmar Berger

  • Stefanie Müllerke

  • Jonas Wizenty

  • Hans-Joachim Mollenkopf

  • David Horst

  • Frank Tacke

  • Christoph Treese

  • Michael Sigal

  • August 24, 2026

Share

  • 1

    Gastric cancer is the third leading cause of cancer-related mortality globally, with many patients diagnosed at advanced stages.

  • 2

    R-spondin 3 (RSPO3) enhances Wnt signaling and is implicated in gastric carcinogenesis, particularly in response to H. pylori infection.

  • 3

    Current biomarkers for predicting immunotherapy response in gastric cancer, such as PD-L1 expression, are insufficiently predictive.

  • 4

    The study utilized a cohort of 277 patients with gastric tumors to investigate the relationship between RSPO3 levels and immune signaling.

  • 5

    Mouse models were employed to explore the effects of RSPO3 on immune responses and gastric cancer progression.

Original Source(s)

Mesenchymal R-spondin 3 promotes an immunogenic tumor microenvironment with adaptive immune resistance in human gastric adenocarcinoma

  • by Anne-Sophie Fischer, Alexander Arnold, Hilmar Berger, Stefanie Müllerke, Jonas Wizenty, Hans-Joachim Mollenkopf, David Horst, Frank Tacke, Christoph Treese, Michael Sigal

  • August 24, 2026

Related Content

Anatomical site and histological subtype as determinants of Breslow thickness and high-risk features in surgically managed cutaneous melanoma at Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa

Commentary: Impact of HPV vaccine on CIN2+ recurrence after conization: a systematic review and meta-analysis of vaccination timing, valency and surgical margins

Prognostic superiority of volumetric PET parameters (MTV and TLG) over SUV in advanced non-small-cell lung cancer: a systematic review and meta-analysis of univariate and multivariate evidence