Case Report: Subcutaneous sensor-augmented insulin pump therapy in a 510-g preterm infant with hyperglycemia

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Neonatal hyperglycemia affects up to 80% of extremely low birth weight infants and is linked to serious health risks.
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This case reports the first use of combined continuous glucose monitoring and subcutaneous insulin pump therapy in a 510-gram preterm infant.
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A 55-minute intravenous insulin bridge facilitated the transition to subcutaneous insulin therapy after hyperglycemia was detected.
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Over 14 days, the infant's mean glucose level was 162 mg/dL, with 59.4% of readings in the target range, significantly reducing invasive glucose measurements.
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The successful use of sensor-augmented insulin therapy in this case provides a foundation for future neonatal closed-loop trials.

Frontiers In Pediatrics

by Christian Schlunk, Patrick Neuberger, Christina Künle, Martin Holder, Neysan Rafat
June 18, 2026

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