Diagnostic performance and pathologic associations of the UroVysion assay in patients with upper tract lesions and negative urinary cytology: a large-scale real-world study of 1,256 patients - Takeaways - MDSpire
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UroVysion Test Accuracy and Pathologic Correlates in 1,256 Patients With Upper Tract Lesions and Negative Urine Cytology: A Real-World Study

  • By

  • Longtao Zheng

  • Bao Guan

  • Zheng Wu

  • Yi Ding

  • Bei Zhang

  • Xuesong Li

  • Yanqing Gong

  • October 18, 2026

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  • 1

    This retrospective, 2-center study included 1,256 patients with upper tract lesions, negative urinary cytology, and preoperative UroVysion testing.

  • 2

    UTUC was confirmed in 1,007 patients, while 249 patients were classified as noncancer based on benign pathology or negative biopsy with stable imaging follow-up.

  • 3

    All 3 consecutive urine cytology examinations had to be negative under the reporting system in use at the time.

  • 4

    UroVysion positivity required specified chromosomal gains in at least 4 of 25 abnormal cells or homozygous 9p21 deletion in at least 12 cells.

  • 5

    The study assessed UroVysion diagnostic performance and its association with adverse UTUC pathological features, including stage, grade, and lymphovascular invasion.

Original Source(s)

Diagnostic performance and pathologic associations of the UroVysion assay in patients with upper tract lesions and negative urinary cytology: a large-scale real-world study of 1,256 patients

  • by Longtao Zheng, Bao Guan, Zheng Wu, Yi Ding, Bei Zhang, Xuesong Li, Yanqing Gong

  • October 18, 2026

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