Psychedelics Increase Brain Network Integration - Takeaways - MDSpire

Psychedelics Increase Brain Network Integration

Mega-analysis found stronger connectivity between higher-order and sensorimotor networks, with variable and often minimal within-network changes.

  • By

  • Andrea Surnit

  • April 21, 2026

  • 3 min

Share

  • 1

    Psychedelic drugs enhance functional connectivity between higher-order association networks and sensorimotor networks.

  • 2

    The analysis included 11 datasets with 267 participants, revealing robust connectivity changes across various psychedelics.

  • 3

    Psilocybin and LSD exhibited similar connectivity patterns, while ayahuasca showed distinct decreases in network connectivity.

  • 4

    The study indicates selective patterns of brain network integration rather than widespread disintegration from psychedelics.

  • 5

    Findings are mechanistic and do not establish therapeutic efficacy or specific treatment recommendations for clinical use.

Original Source(s)

Psychedelics Increase Brain Network Integration

  • by Andrea Surnit

  • April 21, 2026

Related Content

Implication of machine learning models versus traditional models for the prediction of suicidal thoughts or ideation in west of Iran; data mining approaches on a population-based cross-sectional study

FaReWell Depression – a randomized controlled trial of a physiotherapeutic program for the facial rehabilitation of wellbeing in depression

GLP-1 Drugs Tied to Lower Addiction Risk

In a target-trial emulation of more than 600,000 veterans, GLP-1 RA initiators saw fewer new substance use disorders—and patients with existing SUDs had fewer overdoses, hospitalizations, and deaths.