A pilot study on therapeutic drug monitoring of asparaginase in Indian children with high-risk ALL: evidence for suboptimal exposure - Takeaways - MDSpire

A pilot study on therapeutic drug monitoring of asparaginase in Indian children with high-risk ALL: evidence for suboptimal exposure

  • By

  • Himanshu Dhanda

  • Shamsuz Zaman

  • Bhavika Rishi

  • Raj Kamal

  • Manpreet Kaur

  • Nitika Anand

  • Baseer Noor

  • Pranay Tanwar

  • Sufian Zaheer

  • Prashant Prabhakar

  • Fouzia Siraj

  • Amitabh Singh

  • Aroonima Misra

  • May 21, 2026

  • 0 min

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  • 1

    Acute lymphoblastic leukemia (ALL) is the most common childhood cancer in India, with survival rates significantly lower than in high-income countries.

  • 2

    The study found consistently subtherapeutic trough asparaginase levels in high-risk pediatric ALL patients, indicating inadequate drug exposure during therapy.

  • 3

    Among the nine patients, three died from treatment-related complications, highlighting the risks associated with insufficient asparaginase activity.

  • 4

    Higher asparaginase activity correlated with various toxicities, including hepatotoxicity and elevated blood urea nitrogen, necessitating careful monitoring.

  • 5

    The findings suggest that therapeutic drug monitoring could optimize asparaginase dosing and minimize toxicity in resource-limited settings like India.

Original Source(s)

A pilot study on therapeutic drug monitoring of asparaginase in Indian children with high-risk ALL: evidence for suboptimal exposure

  • by Himanshu Dhanda, Shamsuz Zaman, Bhavika Rishi, Raj Kamal, Manpreet Kaur, Nitika Anand, Baseer Noor, Pranay Tanwar, Sufian Zaheer, Prashant Prabhakar, Fouzia Siraj, Amitabh Singh, Aroonima Misra

  • May 21, 2026

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