Development and internal validation of a nomogram for predicting adverse pregnancy outcomes in women with early-onset preeclampsia - Takeaways - MDSpire

Development and internal validation of a nomogram for predicting adverse pregnancy outcomes in women with early-onset preeclampsia

  • By

  • Haiqiong Ye

  • Qinlin Zheng

  • June 17, 2026

  • 0 min

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  • 1

    A nomogram was developed to predict adverse pregnancy outcomes in women with early-onset preeclampsia (EOPE) based on clinical data.

  • 2

    The study included 425 women diagnosed with EOPE, with predictors identified through LASSO regression and multivariable logistic regression.

  • 3

    Seven independent predictors were identified: gestational age, systolic blood pressure, urine protein score, platelet count, AST level, fetal growth restriction, and HELLP syndrome.

  • 4

    The nomogram demonstrated good predictive performance with an AUC of 0.859 in the validation cohort, indicating effective risk stratification.

  • 5

    External validation is necessary before clinical implementation, as the proposed risk categories are exploratory and not definitive.

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