Adipokine profiles and genetic variants of leptin receptor, adiponectin, and ghrelin pathways in obesity: prospective 12-month outcomes after bariatric interventions - Takeaways - MDSpire

Adipokine profiles and genetic variants of leptin receptor, adiponectin, and ghrelin pathways in obesity: prospective 12-month outcomes after bariatric interventions

  • By

  • Andriy Prodan

  • Ihor Dzyubanovsky

  • Iryna Halabitska

  • Pavlo Petakh

  • Iryna Kamyshna

  • Oleksandr Kamyshnyi

  • May 20, 2026

  • 0 min

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  • 1

    The study assessed the relationships between genetic polymorphisms, adipokine levels, and metabolic indicators in obese patients.

  • 2

    Resistin and leptin levels increase with obesity, while adiponectin and ghrelin levels decrease, indicating hormonal changes.

  • 3

    The rs1137101 and rs696217 genetic polymorphisms are linked to obesity severity and influence hormonal profiles post-bariatric surgery.

  • 4

    Bariatric surgery significantly reduces BMI, improves glycemic control, and normalizes hormonal profiles in obese patients.

  • 5

    Genetic testing for specific polymorphisms may help predict bariatric treatment outcomes and personalize obesity therapy.

Original Source(s)

Adipokine profiles and genetic variants of leptin receptor, adiponectin, and ghrelin pathways in obesity: prospective 12-month outcomes after bariatric interventions

  • by Andriy Prodan, Ihor Dzyubanovsky, Iryna Halabitska, Pavlo Petakh, Iryna Kamyshna, Oleksandr Kamyshnyi

  • May 20, 2026

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