Digitalis Reduces HF Events but Not Mortality - Takeaways - MDSpire
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Digitalis Reduces HF Events but Not Mortality

Meta-analysis of randomized trials found fewer worsening heart failure events among patients with reduced or mildly reduced ejection fraction

  • By

  • Andrea Surnit

  • May 12, 2026

  • 4 min

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  • 1

    Digitalis glycosides reduce worsening heart failure events.

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    No reduction in mortality was found.

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    Analyzed data from 9,013 patients.

  • 4

    Primary composite outcome showed an HR of 0.

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    Main contributor to the meta-analysis was the DIG trial.

  • 6

    Findings consistent across various treatments.

  • 7

    Modern therapy may redefine the role of digitalis.

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    Safety profiles were similar between treatment groups.

Original Source(s)

Digitalis Reduces HF Events but Not Mortality

  • by Andrea Surnit

  • May 12, 2026

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