Promising effects of high-intensity focused ultrasound combined with eribulin and sintilimab in a patient with advanced leiomyosarcoma: a case report and literature review - Takeaways - MDSpire

Promising effects of high-intensity focused ultrasound combined with eribulin and sintilimab in a patient with advanced leiomyosarcoma: a case report and literature review

  • By

  • Shaoli Li

  • Menglei Jin

  • Qunan Sun

  • Hui Wang

  • Xiaoye Hu

  • Rui Bai

  • Ying Dong

  • July 9, 2026

  • 0 min

Share

  • 1

    Leiomyosarcoma (LMS) is an aggressive malignancy with a high risk of recurrence and poor prognosis due to limited treatment options.

  • 2

    A 49-year-old male with advanced bladder LMS achieved disease stabilization with eribulin and sintilimab after prior therapies failed.

  • 3

    The addition of high-intensity focused ultrasound (HIFU) led to a partial response, maintained for 7.2 months with continued systemic therapy.

  • 4

    The case suggests a potential synergistic effect of combining local and systemic therapies in treating advanced LMS.

  • 5

    The patient remains alive with an overall survival of 57 months since the initial diagnosis, highlighting the need for novel therapeutic strategies.

Original Source(s)

Promising effects of high-intensity focused ultrasound combined with eribulin and sintilimab in a patient with advanced leiomyosarcoma: a case report and literature review

  • by Shaoli Li, Menglei Jin, Qunan Sun, Hui Wang, Xiaoye Hu, Rui Bai, Ying Dong

  • July 9, 2026

Related Content

Risk stratification model based on estimated dose of radiation to immune cells and radiotherapy-related nadir lymphocyte count for predicting the efficacy of consolidation immunotherapy in stage III non-small cell lung cancer

Long-term outcomes of definitive chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil for postoperative locoregional recurrent esophageal cancer: a prospective phase II study

Sequential gemcitabine–docetaxel in BCG-naïve and BCG-failure non–muscle-invasive bladder cancer: a systematic review and meta-analysis