ASNS-dependent asparagine availability supports intestinal ILC2 responses and type 2 immunity under nutrient-limited conditions - Takeaways - MDSpire
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The Role of ASNS-Mediated Asparagine Availability in Supporting Intestinal ILC2 Function and Type 2 Immune Responses in Nutrient-Restricted Environments

  • By

  • Wenyu Tian

  • Xuesong Liu

  • Mengqi Zheng

  • Jing Shen

  • September 15, 2026

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  • 1

    Asparagine (Asn) is essential for the survival and activity of intestinal group 2 innate lymphoid cells (ILC2s).

  • 2

    ILC2s rely on asparagine synthetase (ASNS) for de novo Asn biosynthesis, especially under extracellular Asn limitation.

  • 3

    Genetic deletion of ASNS reduces ILC2 viability and effector cytokine production in Asn-restricted environments.

  • 4

    Dietary Asn limitation compromises ILC2 function, with ASNS deficiency exacerbating this effect during type 2 inflammation.

  • 5

    Nippostrongylus brasiliensis infection increases ILC2 dependence on ASNS for maintaining abundance and protective immunity.

Original Source(s)

ASNS-dependent asparagine availability supports intestinal ILC2 responses and type 2 immunity under nutrient-limited conditions

  • by Wenyu Tian, Xuesong Liu, Mengqi Zheng, Jing Shen

  • September 15, 2026

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