Clear Liquid Diets and Enhanced Safety in Procedures: Insights from the OCULUS Trial—A Response

1

The OCULUS trial highlighted the importance of clear liquid diets in reducing clinically significant residual gastric volume (CS-RGV) during upper endoscopy.
2

No CS-RGV was detected among OCULUS participants who adhered to a 24-hour clear liquid diet, regardless of medication continuation.
3

The ongoing OCULUS-2 trial is examining the effects of holding versus continuing GLP-1/GIP RAs during bowel preparation.
4

Recent guidelines suggest stratifying CS-RGV risk for patients on GLP-1/GIP RAs, emphasizing the need for careful patient selection.
5

There is a lack of evidence on patient preferences regarding dietary modification and medication withholding, indicating a gap in clinical decision-making.

1