Association of SARS-CoV-2 With Health-related Quality of Life 1 Year After Illness Using Latent Transition Analysis

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The study assessed health-related quality of life (HRQoL) in adults with COVID-19-like illness over 12 months post-infection.
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COVID+ participants showed significant recovery in physical HRQoL by 3 months, while mental HRQoL improved more gradually by 9 months.
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Approximately 20% of participants experienced suboptimal HRQoL from 3 to 12 months after SARS-CoV-2 infection.
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Four distinct HRQoL classes were identified: optimal overall, poor mental, poor physical, and poor overall HRQoL.
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COVID+ participants were more likely to transition to the optimal HRQoL class compared to COVID− participants.

Open Forum Infectious Diseases

by Lauren E Wisk, Michael Gottlieb, Peizheng Chen, Huihui Yu, Kelli N O’Laughlin, Kari A Stephens, Graham Nichol, Juan Carlos C Montoy, Robert M Rodriguez, Michelle Santangelo, Kristyn Gatling, Erica S Spatz, Arjun K Venkatesh, Kristin L Rising, Mandy J Hill, Ryan Huebinger, Ahamed H Idris, Michael Willis, Efrat Kean, Samuel A McDonald, Joann G Elmore, Robert A Weinstein, for the INSPIRE Group
June 10, 2025

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