Correction: A mechanovascular framework for pre-neoplastic microenvironmental dysregulation and early carcinogenesis

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The correction includes the previously omitted Abstract, detailing the mechanovascular framework for early carcinogenesis.
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Chronic vasomotor dysregulation and endothelial disruptions contribute to elevated interstitial fluid pressure before tumor formation.
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Endothelin-1 imbalance is proposed to increase capillary hydrostatic pressure, promoting interstitial fluid accumulation.
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Disruption of microvascular homeostasis affects glucose uptake and glycolytic flux, favoring a sustained glycolytic phenotype.
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The framework suggests that restoring vascular-interstitial homeostasis may be a strategy for early cancer interception.

Frontiers In Oncology

by Amal Bhanu Vayakkattil, Aiswarya Sivan Pazhanchery, Varsha Vijayarajan, Udayabhanu Vayakkattil
July 16, 2026

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