Case Study: Misdiagnosis Due to Overlapping Symptoms in a Patient with Major Depression Subsequently Found to Have Systemic Amyloidosis

1

Systemic amyloidosis can present with non-specific symptoms that overlap with major depression, leading to diagnostic delays.
2

A 57-year-old male patient initially diagnosed with major depression was later found to have systemic amyloidosis with cardiac involvement.
3

The patient's treatment for depression included duloxetine and olanzapine, but symptoms persisted and worsened, leading to further investigation.
4

Cardiac involvement is the primary cause of morbidity and mortality in systemic amyloidosis, complicating its diagnosis.
5

Increased interdisciplinary awareness and reduced cognitive bias are necessary to prevent misdiagnosis in patients with overlapping symptoms.

1