Case Report: Continuous block-and-replace strategy with osilodrostat in a patient with cyclic Cushing’s syndrome - Takeaways - MDSpire

Case Report: Continuous block-and-replace strategy with osilodrostat in a patient with cyclic Cushing’s syndrome

  • By

  • Wiktoria Suchy

  • Mari Minasyan

  • Aleksandra Gamrat-Żmuda

  • Alicja Hubalewska-Dydejczyk

  • Aleksandra Gilis-Januszewska

  • July 9, 2026

  • 0 min

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  • 1

    Cyclic Cushing's syndrome (cCS) is characterized by recurrent peaks of hypercortisolism followed by spontaneous remissions.

  • 2

    A 68-year-old male with cCS experienced severe infections and metabolic disturbances, leading to multiple hospitalizations.

  • 3

    Dynamic tests indicated an ectopic origin of ACTH-dependent Cushing's syndrome in the patient.

  • 4

    The patient was treated with a continuous block-and-replace regimen using osilodrostat, achieving biochemical stabilization.

  • 5

    Inferior petrosal sinus sampling is planned to definitively establish the etiology of the patient's Cushing's syndrome.

Original Source(s)

Case Report: Continuous block-and-replace strategy with osilodrostat in a patient with cyclic Cushing’s syndrome

  • by Wiktoria Suchy, Mari Minasyan, Aleksandra Gamrat-Żmuda, Alicja Hubalewska-Dydejczyk, Aleksandra Gilis-Januszewska

  • July 9, 2026

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