Dendrobine inhibits anaplastic thyroid cancer progression by targeting the JAK-STAT3 pathway - Takeaways - MDSpire

Dendrobine inhibits anaplastic thyroid cancer progression by targeting the JAK-STAT3 pathway

  • By

  • Yanhuan Shang

  • Dan Zhang

  • June 2, 2026

  • 0 min

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  • 1

    Dendrobine significantly reduces the viability of anaplastic thyroid carcinoma (ATC) cells, with 5 μM showing the most pronounced inhibition.

  • 2

    Treatment with dendrobine suppresses cell proliferation and colony formation while increasing apoptosis in ATC cell lines.

  • 3

    Dendrobine inhibits migration and invasion of ATC cells and modulates epithelial-mesenchymal transition markers.

  • 4

    The compound suppresses phosphorylation of JAK1, JAK2, and STAT3, indicating its mechanism involves the JAK-STAT3 signaling pathway.

  • 5

    In vivo, dendrobine reduces tumor volume and weight in mice without nephrotoxic effects, highlighting its therapeutic potential.

Original Source(s)

Dendrobine inhibits anaplastic thyroid cancer progression by targeting the JAK-STAT3 pathway

  • by Yanhuan Shang, Dan Zhang

  • June 2, 2026

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