Early Changes in Creatinine Levels Predict Outcomes in Patients with Sepsis - Takeaways - MDSpire

Early Changes in Creatinine Levels Predict Outcomes in Patients with Sepsis

  • By

  • Dan Liu

  • Zhonglin Zhang

  • Aihua Qin

  • Xiaofeng Li

  • Jian Zhao

  • Huihua Jiang

  • Yi Zhao

  • Yuanzhuo Chen

  • Hu Peng

  • February 19, 2026

  • 0 min

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  • 1

    Sepsis is a critical condition leading to high ICU admission rates and a mortality rate up to 40%, necessitating early identification of death-related indicators.

  • 2

    Serum creatinine levels are linked to renal function and can predict adverse outcomes in sepsis patients, particularly in diagnosing acute kidney injury.

  • 3

    The study utilized the MIMIC-IV database, analyzing data from 8663 ICU patients diagnosed with sepsis according to the sepsis 3.0 criteria.

  • 4

    Latent class trajectory models (LCTM) were employed to classify creatinine trajectories over 72 hours, aiding in identifying high-risk sepsis patients.

  • 5

    The study aimed to explore the relationship between early changes in creatinine levels and unfavorable prognosis in sepsis patients.

Original Source(s)

Early Changes in Creatinine Levels Predict Outcomes in Patients with Sepsis

  • by Dan Liu, Zhonglin Zhang, Aihua Qin, Xiaofeng Li, Jian Zhao, Huihua Jiang, Yi Zhao, Yuanzhuo Chen, Hu Peng

  • February 19, 2026

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