Metachronous multicentric giant cell tumor of bone with pulmonary metastases: a case report with 20-year follow-up - Takeaways - MDSpire
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A Case Study of Metachronous Multicentric Giant Cell Tumor of Bone with Lung Metastases: 20-Year Follow-Up Analysis

  • By

  • Lei Zhao

  • Wei Wang

  • Guohui Liang

  • Zhicai Zhang

  • Jianxiang Liu

  • Binlong Zhong

  • May 7, 2026

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  • 1

    Metachronous multicentric giant cell tumor of bone (MGCTB) with pulmonary metastases is an exceedingly rare and challenging condition.

  • 2

    The patient, a 38-year-old male, was followed for over 20 years, undergoing multiple surgical interventions for MGCTB.

  • 3

    Denosumab therapy, initiated in 2017, achieved sustained disease stabilization despite previous treatment failures.

  • 4

    A treatment interruption during the COVID-19 pandemic led to disease progression, necessitating further surgical intervention.

  • 5

    This case highlights the importance of continuous systemic therapy in managing advanced MGCTB and controlling metastatic disease.

Original Source(s)

Metachronous multicentric giant cell tumor of bone with pulmonary metastases: a case report with 20-year follow-up

  • by Lei Zhao, Wei Wang, Guohui Liang, Zhicai Zhang, Jianxiang Liu, Binlong Zhong

  • May 7, 2026

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