Misclassification of sepsis using ICD-10 codes A00–B99 in the study - Takeaways - MDSpire

Misclassification of sepsis using ICD-10 codes A00–B99 in the study

  • By

  • Ziyan Gan

  • Qiang Li

  • Yonglin Li

  • December 1, 2025

  • 0 min

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  • 1

    The classification of sepsis using ICD-10 codes A00–B99 is methodologically flawed and does not accurately identify true sepsis cases.

  • 2

    ICD-10 codes A00–B99 encompass a wide range of mild infections, leading to misclassification of patients as having sepsis.

  • 3

    True sepsis should be identified using specific ICD-10 codes like R65.20 or A41.9, often combined with organ dysfunction markers.

  • 4

    The misclassification of sepsis may explain the unexpectedly low incidence of sepsis-induced cardiomyopathy reported in the study.

  • 5

    The authors are encouraged to clarify this limitation and consider using validated sepsis algorithms for more accurate analysis.

Original Source(s)

Misclassification of sepsis using ICD-10 codes A00–B99 in the study

  • by Ziyan Gan, Qiang Li, Yonglin Li

  • December 1, 2025

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