Age- and sex-based risk stratification in takotsubo syndrome: a Japanese nationwide registry study - Takeaways - MDSpire

Age- and sex-based risk stratification in takotsubo syndrome: a Japanese nationwide registry study

  • By

  • Tomohiro Hayashi

  • Kazuaki Negishi

  • Takato Kobayashi

  • Koshiro Kanaoka

  • Hozuka Akita

  • Yuto Shinkura

  • Ryo Nishio

  • Kensuke Matsumoto

  • Masahiko Hoshijima

  • Satoru Kawasaki

  • Hogara Nishisaki

  • Masanobu Okayama

  • Tsuneaki Kenzaka

  • July 1, 2026

  • 0 min

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  • 1

    The study analyzed 13,585 patients with takotsubo syndrome (TTS) using a nationwide Japanese registry from 2012 to 2022.

  • 2

    Men with TTS had higher rates of comorbidities and required more intensive care compared to women.

  • 3

    In-hospital mortality rates for men increased with age, reaching 8.2% in those aged 75 and older.

  • 4

    Older age and male sex were identified as independent predictors of in-hospital mortality in TTS patients.

  • 5

    The findings highlight the need for age- and sex-specific risk assessment in managing TTS patients.

Original Source(s)

Age- and sex-based risk stratification in takotsubo syndrome: a Japanese nationwide registry study

  • by Tomohiro Hayashi, Kazuaki Negishi, Takato Kobayashi, Koshiro Kanaoka, Hozuka Akita, Yuto Shinkura, Ryo Nishio, Kensuke Matsumoto, Masahiko Hoshijima, Satoru Kawasaki, Hogara Nishisaki, Masanobu Okayama, Tsuneaki Kenzaka

  • July 1, 2026

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