Developing and validating a lactate-to-albumin ratio-enhanced score for mortality prediction in ICU patients with acute pulmonary embolism: a multi-cohort study - Takeaways - MDSpire

Developing and validating a lactate-to-albumin ratio-enhanced score for mortality prediction in ICU patients with acute pulmonary embolism: a multi-cohort study

  • By

  • Jun An

  • Peng Liu

  • Yingqun Ji

  • June 15, 2026

  • 0 min

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  • 1

    The study evaluated the lactate-to-albumin ratio (LAR) as a predictor of 28-day mortality in ICU patients with acute pulmonary embolism (APE).

  • 2

    LAR demonstrated a linear relationship with 28-day mortality, with AUC values ranging from 0.610 to 0.710 across different cohorts.

  • 3

    The new scoring system, LAR-sPESI, showed modest improvements in predictive performance compared to the simplified Pulmonary Embolism Severity Index (sPESI).

  • 4

    LAR exhibited moderate discriminative ability for norepinephrine use, while its predictive performance for thrombolysis and mechanical ventilation was limited.

  • 5

    The study suggests that LAR may serve as a preliminary predictor of mortality in ICU patients with APE, supporting exploratory risk stratification.

Original Source(s)

Developing and validating a lactate-to-albumin ratio-enhanced score for mortality prediction in ICU patients with acute pulmonary embolism: a multi-cohort study

  • by Jun An, Peng Liu, Yingqun Ji

  • June 15, 2026

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