Editorial: Genetics, microbiomes, and environmental factors in autoimmunity: from bench to bedside - Takeaways - MDSpire
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Editorial: The Role of Genetics, Microbiomes, and Environmental Influences in Autoimmune Disorders: Translating Research into Clinical Practice

  • By

  • Shaharir, Syahrul Sazliyana

  • Ali, Adli

  • Adeeb, Fahd

  • June 9, 2026

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  • 1

    A profound polygenic overlap exists between inflammatory bowel disease (IBD) and rheumatoid arthritis (RA), with specific shared loci identified.

  • 2

    The IL1B rs16944 polymorphism is significantly associated with increased risk of idiopathic inflammatory myopathies in Mexican mestizo patients.

  • 3

    Genetic variants in rheumatoid arthritis, such as HLA-DRB1 and PTPN22, contribute to autoantibody production and disease progression.

  • 4

    Environmental exposures, particularly viral infections, may trigger autoimmune diseases in genetically susceptible individuals.

  • 5

    Future research should focus on integrating genomics and environmental science to enhance understanding and treatment of autoimmune disorders.

Original Source(s)

Editorial: Genetics, microbiomes, and environmental factors in autoimmunity: from bench to bedside

  • by Shaharir, Syahrul Sazliyana , Ali, Adli , Adeeb, Fahd

  • June 9, 2026

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