Aegeline mitigates isoproterenol-induced myocardial infarction: insights from biochemical, histopathological, and in silico studies - Takeaways - MDSpire

Aegeline Reduces Myocardial Infarction Induced by Isoproterenol: Findings from Biochemical, Histopathological, and In Silico Analyses

  • By

  • Sami I. Alzarea

  • Muhammad Afzal

  • Misbahuddin Rafeeq

  • Alaa Hamed Habib

  • Tariq G. Alsahli

  • Omar Awad Alsaidan

  • Hassan H. Alhassan

  • Abdulaziz Ibrahim Alzarea

  • Aseel Awad Alsaidan

  • Nadeem Sayyed

  • Imran Kazmi

  • July 21, 2026

Share

  • 1

    Aegeline, an alkaloidal amide from Aegle marmelos, shows potential cardioprotective effects against isoproterenol-induced myocardial infarction.

  • 2

    In experimental models, aegeline reduced myocardial damage and improved oxidative stress and inflammatory markers without affecting liver or kidney function.

  • 3

    Molecular docking studies indicated strong binding affinity of aegeline to CK-MB, with favorable interactions also noted with LDH, cTnT, and cTnI.

  • 4

    The study utilized isoproterenol to induce myocardial injury in rats, mimicking mechanisms of human myocardial infarction.

  • 5

    Aegeline's cardioprotective activity is supported by biochemical, histopathological, and computational analyses demonstrating its effects on myocardial injury.

Original Source(s)

Aegeline mitigates isoproterenol-induced myocardial infarction: insights from biochemical, histopathological, and in silico studies

  • by Sami I. Alzarea, Muhammad Afzal, Misbahuddin Rafeeq, Alaa Hamed Habib, Tariq G. Alsahli, Omar Awad Alsaidan, Hassan H. Alhassan, Abdulaziz Ibrahim Alzarea, Aseel Awad Alsaidan, Nadeem Sayyed, Imran Kazmi

  • July 21, 2026

Related Content

Opioid and benzodiazepine requirements in neonatal and pediatric patients undergoing venoarterial ECMO: insights from a predominantly cardiac cohort

Linear accelerator–based stereotactic arrhythmia radioablation for paroxysmal atrial fibrillation in elderly patients: results from long-term follow-up

Dynamic triage in hypertension: a quantitative framework for follow-up scheduling based on clinician heuristics and home blood pressure data