C-Reactive Protein for Pulmonary Tuberculosis Screening and Treatment Response Monitoring in Children - Takeaways - MDSpire

C-Reactive Protein for Pulmonary Tuberculosis Screening and Treatment Response Monitoring in Children

  • By

  • Joy Githua

  • Jerphason Mecha

  • Joshua Stern

  • Jaclyn N Escudero

  • Lilian Njagi

  • Lucy Kijaro

  • Jacqueline Mirera

  • Wilfred Murithi

  • Grace John-Stewart

  • Elizabeth Maleche-Obimbo

  • Videlis Nduba

  • Sylvia M LaCourse

  • January 7, 2026

  • 0 min

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  • 1

    C-reactive protein (CRP) was assessed as a biomarker for diagnosing and monitoring treatment in pediatric pulmonary tuberculosis in Kenyan children.

  • 2

    The study found CRP's diagnostic sensitivity ranged from 35.5% to 50.0%, indicating suboptimal performance for TB detection.

  • 3

    Median CRP levels significantly decreased during TB treatment, particularly in children with baseline CRP levels ≥5 mg/L.

  • 4

    The study included 292 children, with 6.2% confirmed, 62.7% unconfirmed, and 29.8% unlikely TB diagnoses.

  • 5

    CRP sensitivity was 50.0% at a 5 mg/L threshold for confirmed TB, highlighting the need for improved diagnostic methods.

Original Source(s)

C-Reactive Protein for Pulmonary Tuberculosis Screening and Treatment Response Monitoring in Children

  • by Joy Githua, Jerphason Mecha, Joshua Stern, Jaclyn N Escudero, Lilian Njagi, Lucy Kijaro, Jacqueline Mirera, Wilfred Murithi, Grace John-Stewart, Elizabeth Maleche-Obimbo, Videlis Nduba, Sylvia M LaCourse

  • January 7, 2026

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