HRS-7535 for Type 2 Diabetes Inadequately Controlled With Metformin: A Randomized Clinical Trial - Takeaways - MDSpire

HRS-7535 for Type 2 Diabetes Inadequately Controlled With Metformin: A Randomized Clinical Trial

  • By

  • Lixin Guo

  • Zilin Sun

  • Lihui Zhang

  • Guijun Qin

  • Yulan Li

  • Xiaopan Chen

  • Na Xu

  • Xiuhai Su

  • Li Mao

  • Jiao Sun

  • Zhifeng Cheng

  • Xiaoguang Shi

  • Fang Wang

  • Qi Wang

  • Ruirong Pan

  • Shan Ding

  • Zi Ye

  • Yimei Xu

  • Pan Liu

  • June 3, 2026

  • 0 min

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  • 1

    HRS-7535 is an oral small-molecule GLP-1 RA evaluated for efficacy and safety in patients with type 2 diabetes inadequately controlled by metformin.

  • 2

    The phase 2 trial involved 180 participants, randomized to receive HRS-7535 at varying doses or placebo over a 16-week period.

  • 3

    The primary endpoint was the change in HbA1c levels from baseline at week 16, with secondary endpoints including various glucose and weight measures.

  • 4

    Safety assessments included monitoring for adverse events, hypoglycemic events, and other vital parameters throughout the trial.

  • 5

    The trial adhered to ethical guidelines and was conducted at 44 sites in China, with all participants providing informed consent.

Original Source(s)

HRS-7535 for Type 2 Diabetes Inadequately Controlled With Metformin: A Randomized Clinical Trial

  • by Lixin Guo, Zilin Sun, Lihui Zhang, Guijun Qin, Yulan Li, Xiaopan Chen, Na Xu, Xiuhai Su, Li Mao, Jiao Sun, Zhifeng Cheng, Xiaoguang Shi, Fang Wang, Qi Wang, Ruirong Pan, Shan Ding, Zi Ye, Yimei Xu, Pan Liu

  • June 3, 2026

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