Naringin and denosumab ameliorate osteoporosis and suppress the aldosterone-MR/SGK1 signaling axis by modulating the bone-kidney interorgan communication in Orchiectomized rats - Takeaways - MDSpire
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Naringin and Denosumab Improve Osteoporosis and Inhibit the Aldosterone-MR/SGK1 Pathway by Influencing Bone-Kidney Interactions in Orchiectomized Rats

  • By

  • Shishuo Xiong

  • Guoying Wu

  • Yelin Zhong

  • Rong Xiang

  • Yukai Zhang

  • Haiwei Guo

  • Zehua Guo

  • Wenhao Lu

  • Qing Lan

  • Yongzhen Chen

  • Ying Li

  • June 30, 2026

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  • 1

    Naringin and denosumab were tested in orchiectomized male rats to evaluate their effects on osteoporosis and the aldosterone-MR/SGK1 pathway.

  • 2

    Both treatments significantly increased bone mineral density and improved trabecular microarchitecture in the rat model.

  • 3

    Naringin and denosumab suppressed the elevation of serum aldosterone induced by orchiectomy.

  • 4

    Molecular analyses showed that both treatments inhibited the MR/SGK1 signaling pathway in the kidney and reduced MR expression in bone.

  • 5

    This study provides evidence for a bidirectional communication between bone and kidney, suggesting a functional 'bone-kidney' axis.

Original Source(s)

Naringin and denosumab ameliorate osteoporosis and suppress the aldosterone-MR/SGK1 signaling axis by modulating the bone-kidney interorgan communication in Orchiectomized rats

  • by Shishuo Xiong, Guoying Wu, Yelin Zhong, Rong Xiang, Yukai Zhang, Haiwei Guo, Zehua Guo, Wenhao Lu, Qing Lan, Yongzhen Chen, Ying Li

  • June 30, 2026

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