Naringin and denosumab ameliorate osteoporosis and suppress the aldosterone-MR/SGK1 signaling axis by modulating the bone-kidney interorgan communication in Orchiectomized rats

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Naringin and denosumab were tested in orchiectomized male rats to evaluate their effects on osteoporosis and the aldosterone-MR/SGK1 pathway.
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Both treatments significantly increased bone mineral density and improved trabecular microarchitecture in the rat model.
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Naringin and denosumab suppressed the elevation of serum aldosterone induced by orchiectomy.
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Molecular analyses showed that both treatments inhibited the MR/SGK1 signaling pathway in the kidney and reduced MR expression in bone.
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This study provides evidence for a bidirectional communication between bone and kidney, suggesting a functional 'bone-kidney' axis.

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