Integrating genomic structural equation modeling and experimental validation to unravel the genetic basis of male genital lichen sclerosus - Takeaways - MDSpire

Integrating genomic structural equation modeling and experimental validation to unravel the genetic basis of male genital lichen sclerosus

  • By

  • Jianbai Chen

  • Zhiming Zhang

  • Qiang Fu

  • Haozhong Hou

  • Gongquan Xu

  • Zhenyu Li

  • Zhiguo Lu

  • Jianxin Qiu

  • Ke Wu

  • Xiaoping Gao

  • Geng Zhang

  • Longfei Yang

  • Rundong Song

  • Wei Zhang

  • July 16, 2026

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  • 1

    The study investigates the genetic architecture of male genital lichen sclerosus (MGLSc) using genomic structural equation modeling (Genomic-SEM).

  • 2

    A total of 208 SNPs reached genome-wide significance, identifying 43 risk loci and 14 candidate genes associated with MGLSc.

  • 3

    HLA-DPA1 was identified as the most significant gene, with its expression significantly decreased in MGLSc samples compared to controls.

  • 4

    The study utilized multi-omics analyses, including fine-mapping and transcriptome-wide association studies, to explore genetic underpinnings.

  • 5

    Results indicate that MGLSc is influenced by a polygenic architecture enriched in immune-related loci, particularly within the HLA region.

Original Source(s)

Integrating genomic structural equation modeling and experimental validation to unravel the genetic basis of male genital lichen sclerosus

  • by Jianbai Chen, Zhiming Zhang, Qiang Fu, Haozhong Hou, Gongquan Xu, Zhenyu Li, Zhiguo Lu, Jianxin Qiu, Ke Wu, Xiaoping Gao, Geng Zhang, Longfei Yang, Rundong Song, Wei Zhang

  • July 16, 2026

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