Influence of age and sex on the diagnostic yield of inherited cardiac conditions in sudden arrhythmic death syndrome decedents - Takeaways - MDSpire

Influence of age and sex on the diagnostic yield of inherited cardiac conditions in sudden arrhythmic death syndrome decedents

  • By

  • Belinda Gray

  • Elijah R Behr

  • Efstathios Papatheodorou

  • Athanasios Bakalakos

  • Hariharan Raju

  • Yanushi D Wijeyeratne

  • Gherardo Finocchiaro

  • Aneil Malhotra

  • Nicola Whiffin

  • James S Ware

  • Maria Tome Esteban

  • Mary N Sheppard

  • Sanjay Sharma

  • Michael Papadakis

  • December 23, 2024

  • 0 min

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  • 1

    The overall diagnostic yield for inherited cardiac conditions in SADS decedents was 37%, increasing to 45% when both familial evaluation and molecular autopsy were performed.

  • 2

    Females demonstrated a higher diagnostic yield for inherited cardiac conditions compared to males, particularly for long QT syndrome.

  • 3

    The likelihood of diagnosing long QT syndrome and catecholaminergic polymorphic ventricular tachycardia decreased with each year of increasing age.

  • 4

    Younger decedents, especially children and adolescents, had the highest diagnostic yield for inherited cardiac conditions following SADS.

  • 5

    Comprehensive familial evaluation and molecular autopsy are crucial in identifying underlying diagnoses after sudden arrhythmic death syndrome.

Original Source(s)

Influence of age and sex on the diagnostic yield of inherited cardiac conditions in sudden arrhythmic death syndrome decedents

  • by Belinda Gray, Elijah R Behr, Efstathios Papatheodorou, Athanasios Bakalakos, Hariharan Raju, Yanushi D Wijeyeratne, Gherardo Finocchiaro, Aneil Malhotra, Nicola Whiffin, James S Ware, Maria Tome Esteban, Mary N Sheppard, Sanjay Sharma, Michael Papadakis

  • December 23, 2024

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