Systematic Review and Meta-Analysis of Peripheral Nerve Blocks for Treating Medication-Overuse Headache - Takeaways - MDSpire

Systematic Review and Meta-Analysis of Peripheral Nerve Blocks for Treating Medication-Overuse Headache

  • By

  • Piero A. Arias-Tello

  • Carlos F. Coronado-Caceres

  • Mario E. Serrano-Sablich

  • Guillemo Mantilla

  • Maria Teresa Goicochea

  • Christoper A. Alarcon-Ruiz

  • February 7, 2026

  • 0 min

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  • 1

    Medication-overuse headache (MOH) affects individuals with primary headache disorders, leading to significant disability and high healthcare consultations.

  • 2

    Peripheral nerve blocks, particularly greater occipital nerve blocks, may provide short-term relief and reduce headache frequency in MOH patients.

  • 3

    The systematic review aims to evaluate the efficacy and safety of peripheral nerve blocks compared to standard treatments for MOH.

  • 4

    Current evidence suggests peripheral nerve blocks may reduce headache days when combined with preventive medication, but uncertainties remain.

  • 5

    Adverse effects of peripheral nerve blocks include nerve injury and infection, highlighting the need for careful evaluation in MOH treatment.

Original Source(s)

Systematic Review and Meta-Analysis of Peripheral Nerve Blocks for Treating Medication-Overuse Headache

  • by Piero A. Arias-Tello, Carlos F. Coronado-Caceres, Mario E. Serrano-Sablich, Guillemo Mantilla, Maria Teresa Goicochea, Christoper A. Alarcon-Ruiz

  • February 7, 2026

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