Multiple myeloma: A tale of deregulated transcription factors - Takeaways - MDSpire
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Transcription Factor Dysregulation in Multiple Myeloma: An Overview

  • By

  • Nahia Gómez-Echarte

  • Edurne San José-Enériz

  • Estíbaliz Urizar-Compains

  • Paula Rodriguez-Otero

  • Felipe Prósper

  • Xabier Agirre

  • July 1, 2026

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  • 1

    Multiple myeloma (MM) is characterized by clonal plasma cell proliferation and often follows premalignant conditions like MGUS and SMM.

  • 2

    Transcription factors (TFs) play a critical role in MM by regulating gene expression networks that sustain myeloma cell survival and contribute to drug resistance.

  • 3

    Recent advances in therapeutic modalities have opened new opportunities for targeting TFs in MM, previously considered 'undruggable'.

  • 4

    TFs are involved in B-cell differentiation into plasma cells, with their precise expression preventing hematopoietic disorders during rapid proliferation.

  • 5

    Cooperative interactions among TFs enhance transcriptional precision and are crucial for lineage-specific transcriptional programs in B-cell development.

Original Source(s)

Multiple myeloma: A tale of deregulated transcription factors

  • by Nahia Gómez-Echarte, Edurne San José-Enériz, Estíbaliz Urizar-Compains, Paula Rodriguez-Otero, Felipe Prósper, Xabier Agirre

  • July 1, 2026

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