From the Journals Conference News Tenecteplase Prior to EVT Did Not Improve Stroke Outcomes Phase 3 trial leaves open the possibility of clinically meaningful benefit or harm in selected late-window patients. By Kathryn Wighton May 14, 2026 6 min Conexiant Share Summary Takeaways 1 TNK-PLUS trial focused on stroke related to middle cerebral artery occlusion. 2 391 adults were randomized to receive tenecteplase or endovascular treatment alone. 3 No significant difference in 90-day functional independence (44% vs 43%). 4 Treatment did not increase the likelihood of functional independence. 5 Similar characteristics observed in both groups. 6 Efficacy and safety data remain inconclusive and should be interpreted with caution.
