Patient-Centered Approach to Surgical Prevention of Ovarian Cancer: A Nonrandomized Clinical Trial - Takeaways - MDSpire

Patient-Centered Approach to Surgical Prevention of Ovarian Cancer: A Nonrandomized Clinical Trial

  • By

  • Karen H. Lu

  • Barbara M. Norquist

  • Gary B. Chisholm

  • Christine B. Peterson

  • Kara C. Long Roche

  • Jamie N. Bakkum-Gamez

  • Iris L. Romero

  • Colleen Feltmate

  • Douglas A. Levine

  • Sarah Kim

  • Andrea R. Hagemann

  • Jeanne Carter

  • Martha Hickey

  • Jamie Crase

  • Kathleen Gavin

  • Deborah Polinsky

  • Alan D. D’Andrea

  • Denise R. Nebgen

  • Elizabeth M. Swisher

  • July 7, 2026

  • 0 min

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  • 1

    Genetic testing has increased awareness of high ovarian cancer risk due to BRCA1, BRCA2, and other pathogenic variants.

  • 2

    Risk-reducing salpingo-oophorectomy (RRSO) is the only evidence-based intervention for high-risk individuals to prevent ovarian cancer.

  • 3

    Interval salpingectomy with delayed oophorectomy (ISDO) aims to reduce ovarian cancer risk while delaying surgical menopause.

  • 4

    The Women Choosing Surgical Prevention trial compares sexual function and menopausal symptoms in high-risk individuals undergoing ISDO or RRSO.

  • 5

    Participants in the trial were premenopausal or perimenopausal individuals aged 30 to 50 years with documented pathogenic variants.

Original Source(s)

Patient-Centered Approach to Surgical Prevention of Ovarian Cancer: A Nonrandomized Clinical Trial

  • by Karen H. Lu, Barbara M. Norquist, Gary B. Chisholm, Christine B. Peterson, Kara C. Long Roche, Jamie N. Bakkum-Gamez, Iris L. Romero, Colleen Feltmate, Douglas A. Levine, Sarah Kim, Andrea R. Hagemann, Jeanne Carter, Martha Hickey, Jamie Crase, Kathleen Gavin, Deborah Polinsky, Alan D. D’Andrea, Denise R. Nebgen, Elizabeth M. Swisher

  • July 7, 2026

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