Efficacy of Zinc-L-Carnosine (Polaprezinc) in Treating Infant Regurgitation: Results from a Two-Center Randomized Controlled Study

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Zinc-L-carnosine (Polaprezinc) is evaluated for treating infant regurgitation in a two-center randomized controlled study.
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The study involved 60 infants aged 4 weeks to 7 months with persistent regurgitation despite non-pharmacological measures.
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Both Hepilor liquido® and thickened formula groups showed significant improvement in I-GERQ-R scores after 8 weeks.
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Hepilor liquido® resulted in a greater reduction in regurgitation frequency and lower treatment costs compared to thickened formula.
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Zinc-L-carnosine is a safe and effective alternative for managing infant regurgitation, warranting further research.

Frontiers In Pediatrics

by Marisa Piccirillo, Maurizio Mennini, Enrico Felici, Angela Mauro, Luca Bernardo, Maria Elisabetta Baldassarre, Erika Renzi, Corrado De Vito, Silvia Furio, Marco Graziani, Giovanna Quatrale, Alessandro Ferretti, Giovanni Di Nardo
April 21, 2026

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