From seropositivity to neurosyphilis: clinical spectrum and diagnostic classification in hospitalized neurology patients: a 16-year retrospective study - Takeaways - MDSpire
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Clinical Spectrum and Diagnostic Categorization of Neurosyphilis in Hospitalized Neurology Patients: A 16-Year Retrospective Analysis of Seropositivity

  • By

  • Duygu Özkan Yaşargün

  • August 25, 2026

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  • 1

    This study analyzed syphilis seropositivity in hospitalized neurology patients over a 16-year period.

  • 2

    Out of 9,172 patients tested, 25 were included, with 10 classified as confirmed neurosyphilis and 5 as probable.

  • 3

    MRI findings and positive neurological examinations at discharge significantly differed among diagnostic categories.

  • 4

    No significant differences were found in age, sex, vascular ischemia, HIV status, or vascular involvement on CT.

  • 5

    The study emphasizes the need for comprehensive diagnostic assessments for neurosyphilis beyond seropositivity.

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