Associations between serum amino acids and genetic liability to depression in the LURIC cohort - Takeaways - MDSpire

Links Between Serum Amino Acid Levels and Genetic Predisposition to Depression in the LURIC Study

  • By

  • Robert M. Krämer

  • Graciela E. Delgado

  • Marcus E. Kleber

  • Daniel Duerschmied

  • Winfried März

  • Angela Patricia Moissl-Blanke

  • July 17, 2026

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  • 1

    Major depression affects approximately 7.5% of men and 13.6% of women globally, with a lifetime risk of 20.1% in men and 34.0% in women by age 75.

  • 2

    Circulating amino acids like glutamate and tryptophan are proposed as potential biomarkers for mood disorders due to their roles in neurotransmission.

  • 3

    Previous studies on amino acid profiles in major depression have shown inconsistent results regarding their concentrations in plasma.

  • 4

    The LURIC study enrolled 3,316 patients to investigate the associations between genetic liability to depression and serum amino acid concentrations.

  • 5

    Genetic depression risk scores were calculated using SNPs from genome-wide association studies to assess genetic liability independent of current disease status.

Original Source(s)

Associations between serum amino acids and genetic liability to depression in the LURIC cohort

  • by Robert M. Krämer, Graciela E. Delgado, Marcus E. Kleber, Daniel Duerschmied, Winfried März, Angela Patricia Moissl-Blanke

  • July 17, 2026

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