Association of intratumoral CD68+CD163+ M2-like macrophages with survival in metastatic colorectal cancer treated with chemotherapy plus bevacizumab - Takeaways - MDSpire

Correlation of Intratumoral M2-like Macrophages (CD68+CD163+) with Survival Outcomes in Metastatic Colorectal Cancer Patients Undergoing Chemotherapy and Bevacizumab Treatment

  • By

  • Xiaobin Xin

  • Huixian Qiu

  • Yan Zang

  • Lei Zhou

  • Tao Qin

  • Qingnuan Kong

  • July 17, 2026

Share

  • 1

    Increased proportions of CD68+CD163+ M2-like TAMs are significantly associated with post-treatment resistance in mCRC patients.

  • 2

    High density of intratumoral CD68+CD163+ M2-like TAMs correlates with shorter overall survival in metastatic colorectal cancer patients.

  • 3

    The study analyzed clinical data and tumor tissues from 44 mCRC patients receiving chemotherapy and bevacizumab.

  • 4

    Multivariate Cox regression indicated that dense infiltration of CD68+CD163+ M2-like TAMs is an independent poor prognostic marker.

  • 5

    The findings suggest that targeting macrophages may enhance the efficacy of anti-tumor therapies in metastatic colorectal cancer.

Original Source(s)

Association of intratumoral CD68+CD163+ M2-like macrophages with survival in metastatic colorectal cancer treated with chemotherapy plus bevacizumab

  • by Xiaobin Xin, Huixian Qiu, Yan Zang, Lei Zhou, Tao Qin, Qingnuan Kong

  • July 17, 2026

Related Content

Evidence-based strategies to improve implementation of tumor isolation techniques in colorectal cancer surgery

Robotic-assisted right colectomy with the DEXTER® Robotic Surgery System: first prospective multicenter study

Baptist Health Cancer Care to Present Research on Precision Radiation Therapy Across Complex Cancers at ASTRO 2026

Experts across Baptist Health Herbert Wertheim Cancer Institute and Eugene M. & Christine E. Lynn Cancer Institute will present new radiation oncology research and clinical expertise at the 2026 Annual Meeting of the American Society for Radiation Oncology (ASTRO), September 26-30, 2026, in Boston.

  • by

  • July 7, 2026

  • 8 min