Granulocyte colony-stimulating factor-induced hypersensitivity reaction with leukocytosis in a pediatric germ cell tumor patient: a case report - Takeaways - MDSpire

Granulocyte colony-stimulating factor-induced hypersensitivity reaction with leukocytosis in a pediatric germ cell tumor patient: a case report

  • By

  • Yuhui Tan

  • Chaoyong Wei

  • Wenyan Xiao

  • Yilan Fu

  • Xi Chen

  • Yanxiang Tang

  • Changli Tang

  • June 8, 2026

  • 0 min

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  • 1

    A 14-year-old female with a germ cell tumor developed systemic hypersensitivity reactions after G-CSF administration following chemotherapy.

  • 2

    The patient experienced severe hypotension and hypoxemia within hours of receiving efbemalenograstim alfa-vuxw, indicating a hypersensitivity reaction.

  • 3

    Leukocytosis was noted in the patient, with counts rising significantly after G-CSF administration, suggesting a potential link to the hypersensitivity.

  • 4

    This case is the first documented instance of recurrent hypersensitivity reactions to different G-CSF formulations in a pediatric patient.

  • 5

    The findings emphasize the need for clinical vigilance regarding G-CSF hypersensitivity and the necessity for further safety evaluations in pediatric populations.

Original Source(s)

Granulocyte colony-stimulating factor-induced hypersensitivity reaction with leukocytosis in a pediatric germ cell tumor patient: a case report

  • by Yuhui Tan, Chaoyong Wei, Wenyan Xiao, Yilan Fu, Xi Chen, Yanxiang Tang, Changli Tang

  • June 8, 2026

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