High-frequency ultrasound combined with superb microvascular imaging for differential diagnosis of basal cell carcinoma and seborrheic keratosis: a retrospective analysis with nomogram implementation - Takeaways - MDSpire

High-frequency ultrasound combined with superb microvascular imaging for differential diagnosis of basal cell carcinoma and seborrheic keratosis: a retrospective analysis with nomogram implementation

  • By

  • Guiwu Chen

  • Xiaoling Leng

  • Wenqin Liu

  • Xiaomin Liao

  • Yuting Li

  • Jiaxin Meng

  • Yongjie Cao

  • May 12, 2026

  • 0 min

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  • 1

    High-frequency ultrasound (HFUS) and superb microvascular imaging (SMI) effectively differentiate basal cell carcinoma (BCC) from seborrheic keratosis (SK).

  • 2

    The study analyzed 208 patients, identifying independent predictors of BCC through univariate and multivariate logistic regression analyses.

  • 3

    Key predictors for BCC included larger tumor size, head location, nodular ultrasound pattern, and random vascular flow.

  • 4

    The developed nomogram demonstrated good discriminative performance with an AUC of 0.861, aiding in individualized probability estimation of BCC.

  • 5

    Integrating HFUS and SMI offers a non-invasive diagnostic approach, potentially reducing unnecessary biopsies and improving early detection of malignant lesions.

Original Source(s)

High-frequency ultrasound combined with superb microvascular imaging for differential diagnosis of basal cell carcinoma and seborrheic keratosis: a retrospective analysis with nomogram implementation

  • by Guiwu Chen, Xiaoling Leng, Wenqin Liu, Xiaomin Liao, Yuting Li, Jiaxin Meng, Yongjie Cao

  • May 12, 2026

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